Clicky

The purpose of this study was to assess the epidemiology of hand-foot-mouth disease/herpangina in Taiwan between March 1998 and December 2005. Background: Enterovirus (EV)-related hand, foot, and mouth disease/herpangina (HFMD/HA) has been prevalent in Guangdong Province, China, since 2010. Deaths from severe HFMD/HA varied from year to year (chi(2) for trend = 6.781, P = 0.009). 124 EV71 and 80 CVA16 strains were isolated, among them 56 and 68 EV71 strains were C4a and C4b, while 25 and 55 CVA16 strains were B1a and B1b, respectively. Deaths from severe HFMD/HA varied from year to year (χ2 for trend = 6.781, P = 0.009). Deaths from severe HFMD/HA varied from year to year (χ2 for trend = 6.781, P = 0.009). Wrote the paper: WL YL JW.

We aimed to characterize the EVs involved in an aseptic meningitis outbreak in Korea in 2008. Strains of all three genotypes were at least 94% identical to one another in deduced amino acid sequence. Sigma-Aldrich Products are sold exclusively through Sigma-Aldrich, Inc. View Full Text PDF Listings View primary source full text article PDFs. An epidemiological study in Taiwan revealed that the reported incidence of mild cases of hand-footmouth disease/herpangina (HFMD/HA) varied from year to year; seasonal variations in incidence were observed, with an incidence peak observed during the summer season. The virus is contagious during the incubation period as well. RT-PCR was used to amplify 5′-UTR and VP1 regions of enteroviruses and the serotypes were determined by the sequence comparison using BLAST.


For the purposes of disease prevention and climate change health impact assessment, it is important to understand the temperature–disease association for HFMD in different geographical locations. Furthermore, for the HA model, 88% of the variations among observed HA cases were explained by the linear relationship with the seasonal parameters investigated, which was higher than the 64% observed for the HFMD model. Chip Biotechnology, Shin-Tsu, Taiwan) and the reverse transcription-polymerase chain reaction (RT-PCR) method following conventional virus culture in detecting enterovirus infection in pediatric patients with herpangina or hand-foot-mouth disease. The purpose of our study was to establish a seasonal model to simulate the oscillation of the number of influenza cases with weather conditions and calendar months in Tokyo, Japan, during the winter season. The 1D gene sequences of two EV71 strains were closely related with one another (98.5% nucleotide similarity) and belonged to the C4 genotype. Viral isolation was performed by 11 reference virus laboratories at medical centers as well as the Taiwan Center for Disease Control. Results from viral culture and MR imaging indicated that positive identification of EV71 infection was associated significantly with lesions on MR imaging.

Coxsackievirus A6 (CAV6) is 1 of 10 genotypes within the family Picornaviridae, genus Enterovirus, species Human enterovirus A. The results showed that a total of 14 enterovirus genotypes were identified among HFMD and HA patients in this study. Herpangina was reclassified as a Category V infectious disease subsequent to the implementation of the revised Infectious Diseases Control Law in November 2003. The 1D gene sequences of two EV71 strains were closely related with one another (98.5% nucleotide similarity) and belonged to the C4 genotype. The first case was a 26-month-old boy who presented with a nail deformity on October 2, 2013. The positive rate of enterovirus universal type in the 154 patients with HFMD was 81.82%(126/154). herpangina or hand-foot-and-mouth disease (HFMD)], we performed viral isolation and enterovirus polymerase chain reaction.

The relative risks between weekly HFMD cases and temperature and rainfall were estimated for the period 2001–2008 using time series Poisson regression models allowing for over-dispersion. 2. Smoothing was used to allow non-linear relationship between weather and weekly HFMD cases, and to adjust for seasonality and long-term time trend. The survey period included the year 2000, when HFMD epidemics due to EV71 occurred. HFMD is typically a benign and self-limiting disease. The stool specimen of one affected student tested positive for enterovirus (EV) by the CHP’s Public Health Laboratory Services Branch. Hand, foot and mouth disease (HFMD) and herpangina (HA) are frequently caused by several distinct serotypes belonging to the human enterovirus A species (HEVA).

No significant past medical history, no heart murmurs, no recent sexual activity, rash does not blanch, he has this across his lower extremities, palms of his hand and the mucosal surfaces of his mouth, CBC shows no abnormalities, I choose not to believe this is hand foot mouth disease in a 32 year old male, any help plz? 2011). Coxsackievirus A6 (CV-A6) was identified as the causative pathogen of the outbreak via sequences analysis of products of real-time reverse-transcription polymerase chain reaction (RT-PCR) and nested RT-PCR. All sought medical attention and one of them was discharged after hospitalisation. EV71 vaccines are being evaluated in humans. This is a community-based survey aimed to estimate the disease burden of EV71 in rural central China, especially for HFMD.