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The gene products of herpes simplex virus type 1 UL46 and UL47 enhance the efficiency of alpha TIF (VP16)-mediated alpha gene expression through an unknown mechanism of action. Autophagy is now known to be an essential component of host innate and adaptive immunity. Autophagy is now known to be an essential component of host innate and adaptive immunity. The herpes simplex virus type 1 gamma(1)34.5 gene product precludes the host-mediated protein shutoff response induced by activated protein kinase R (PKR). This article has been cited by other articles in PMC. This article has been cited by other articles in PMC. This article has been cited by other articles in PMC.

The herpes simplex virus type 1 (HSV-1) Us11 gene encodes a multifunctional double-stranded RNA (dsRNA)-binding protein that is expressed late in infection and packaged into the tegument layer of the virus particle. Herpes simplex virus-1 US11 is a RNA-binding protein with a novel RNA-binding domain. Herpes simplex virus type 1 (HSV-1) infection induces profound nucleolar modifications at the functional and organizational levels, including nucleolar invasion by several viral proteins. Our site uses cookies to improve your experience. In cells infected with the herpes simplex virus 1 (HSV-1) recombinant R3616 lacking both copies of the gamma134.5 gene, the double-stranded protein kinase R (PKR) is activated, eIF-2alpha is phosphorylated, and protein synthesis is shut off. We have studied the pathogenic and latency/reactivation potential of a herpes simplex virus type 1 (HSV-1) variant (N38) which has a deletion of four genes, US9, US10, US11, and US12, in the short unique region of the HSV-1 genome. This article has been cited by other articles in PMC.

The US11 protein of herpes simplex virus type 1 (HSV-1) is a small, highly basic phosphoprotein expressed at late times during infection. Marjorie B. The US11 protein of herpes simplex virus type 1 (HSV-1) is a small, highly basic phosphoprotein expressed at late times during infection. The interferon (IFN)-mediated antiviral response is a major defense of the host immune system. Homeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase of the subfamily of dual-specificity Yak1-related kinase proteins. The product of the UL11 gene of herpes simplex virus type 1 (HSV-1) is a 96-amino-acid tegument protein that accumulates on the cytoplasmic face of internal membranes. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays key roles in diverse cellular activities and promotes cell growth and survival.

Herpes simplex virus 1 (HSV-1) facilitates virus entry into cells and cell-to-cell spread by mediating fusion of the viral envelope with cellular membranes and fusion of adjacent cellular membranes. Earlier studies have shown that the UL11 gene of herpes simplex virus encodes a myristylated virion protein and that the UL11 gene enables efficient virion envelopment and export from infected cells. The mechanism(s) by which herpes simplex virus type 1 (HSV-1) latency is established in neurons is not known. PACT, a protein activator of PKR, can cause inhibition of cellular protein synthesis and apoptosis. Growing evidence indicates that herpes simplex virus type 1 (HSV-1) acquires its final envelope in the trans-Golgi network (TGN). Marjorie B. This article has been cited by other articles in PMC.

Herpes simplex virus 1 (HSV-1) facilitates virus entry into cells and cell-to-cell spread by mediating fusion of the viral envelope with cellular membranes and fusion of adjacent cellular membranes. The Us11 protein is a true late gene product of herpes simplex virus type 1 (HSV-1), whose exact function is unknown but which exhibits RNA-binding properties and which is phosphorylated on serine residues. The precise role of each of the seven individual CD11c+ dendritic cell subsets (DCs) identified to date in the response to viral infections is not known. Us11 does not block autophagy by inhibiting Beclin 1 or mTOR. Please check the format of the address you have entered. Plaque morphology of mutant viruses in comparison to HSV-1(F)-YE102. US11 blocks the formation of complex between RIG-I and MAVS or between MDA-5 and MAVS.

Please check the format of the address you have entered. This article has been cited by other articles in PMC. The in vivo persistence of gene-modified cells may be limited by the development of a host immune response to vector-encoded proteins. The infected cell polypeptide 4 (ICP4) of herpes simplex virus 1 (HSV-1) is a regulator of viral transcription that is required for productive infection. Please check the format of the address you have entered. HERPES simplex virus type 1 (HSV-1) Us11 protein, a true late gene product packaged within the virion, is delivered into cells after infection, exhibits a nucleocytoplasmic localization at early times, and later accumulates in the nucleoli1–5. Background In subSaharan Africa, HSV-2 infection is common, and increases risk of HIV transmission and acquisition.

We describe here the neurovirulence properties of a herpes simplex virus type 1 γ34.5 second-site suppressor mutant. We performed a double-blind placebo-controlled trial of oral acyclovir in the treatment of first episodes of genital herpes simplex virus infections in 48 young adults (31 women and 17 men).