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There was no history of head injury preceding the onset of this illness. MRI initially revealed discrete, subcortical, nonenhancing lesions that coalesced and developed enhancement. He developed high fever, headache and disturbance of consciousness on 1st, May, 1998. Varicella zoster virus (VZV) is a leading cause of acute viral encephalitis but little is known about its clinical, biological and imaging features. It thus highlights the need to consider this diagnosis among the differentials for severe unilateral headache in the elderly. Varicella. Worldwide, infection of the central nervous system is the commonest cause of acute encephalitis.

Herpes zoster virus encephalitis if not treated promptly can result in significant morbidity and mortality. The first attack consisted of uncomplicated herpes zoster ophthalmicus. The patient developed MS in 2003 and was switched to fingolimod in 2011, 4 months after discontinuing natalizumab (54 doses). Author manuscript; available in PMC 2010 Feb 1. Author manuscript; available in PMC 2011 Jan 3. Encephalitis can occur at any age, but the highest risk is in children under four years of age, with a peak from three to six months, and among adults, especially those over age 60. Disseminated herpes zoster – defined as having greater than twenty vesicles outside the primary or adjacent dermatome – is uncommon and typically occurs in immunocompromised individuals.

more… Previously we found that cognitive impairment initially occurs in 88% of the HSVE and in 56% of the non-HSV encephalitic patients.23 We now aimed to study (1) does progressive deterioration really occur after acute encephalitis, or (2) do the cognitive deficits found in the acute stage later improve, and (3) how often acute encephalitides cause dementia? As early diagnostic detection is mandatory to prevent long-term sequelae, any clinical indication is helpful to identify patients that are at higher risk of the development of VZV-ME. more… Get a printable copy (PDF file) of the complete article (189K), or click on a page image below to browse page by page. It thus highlights the need to consider this diagnosis among the differentials for severe unilateral headache in the elderly. All patients were treated with acyclovir.

Human herpesvirus (HHV)-6, the causative agent of exanthema subitum, has been associated with a wide spectrum of neurologic complications, including viral (focal) encephalitis. Central diabetes insipidus caused by viral infections has been rarely reported in immunosuppressed patients, such as those with acquired immunodeficiency syndrome or Cushing’s syndrome. These cases, caused by herpes simplex virus, varicella zoster virus and enterovirus, highlight the importance of viral pathogens in causing debilitating infections of the CNS and provide examples of the utility of molecular diagnostics in evaluating patients with encephalitis and meningitis. The clinical syndromes of the VZV-associated diseases comprised meningo-encephalitis, myelitis, myelopathies and polyneuropathies, mostly with a favourable outcome. Influenza A virus could be detected only in a cerebrospinal fluid (CSF) specimen obtained from 1 of 18 patients, despite the use of a highly sensitive polymerase chain reaction assay. If you continue browsing the site, you agree to the use of cookies on this website. You can find out more about our use of cookies in About Cookies, including instructions on how to turn off cookies if you wish to do so.

This intriguing case report poses a series of challenging questions, and eventual authors’ responses and clarifications are expected to add significantly to our limited knowledge in this field. This definition means encephalitis is different from meningitis, which is defined as inflammation of the layers of tissue, or membranes, covering the brain. Pathologically, there is perivascular inflammation, edema, and demyelination within the CNS. Summary: Cerebral vasculitis presenting with intracranial hemorrhage is a rare but known entity. Primary encephalitis is caused by direct infection by the virus, while secondary encephalitis is due to a post-infectious immune reaction to viral infection elsewhere in the body. Encephalitis is a brain disorder due to an acute inflammation of the brain. This article is available to subscribers.

ABSTRACT— EEGs of 42 patients with herpes zoster and 6 with herpes zosterassociated encephalitis were studied to characterize the nature and prevalence of EEG abnormalities in apparently uncomplicated herpes zoster. * Final gross prices may vary according to local VAT. Figure 1. Abnormal spinal fluid findings included mononuclear pleocytosis, occasionally with low glucose concentration. We studied the rare case of an older adult with dementia following herpes zoster encephalitis (HZE). The case of a 74-year-old woman who developed severe behavioural disturbance as part of a frontal lobe syndrome following herpes zoster is described. An 89-year-old lady presented with severe right-sided ophthalmic herpes zoster infection and secondary bacterial infection.

The data from the author’s files and literature are reviewed with respect to the occurrence, clinical characteristics and treatment of encephalitis in children with herpes zoster. Acute encephalitis is an inflammation of the brain parenchyma. We report a case of varicella-zoster virus (VZV) myelitis in a woman with relapsing-remitting multiple sclerosis (RRMS) receiving natalizumab, a humanized monoclonal antibody that induces an immunosuppression localized to the CNS.