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The results were statistically evaluated by Fisher and McNemar tests. This latest study is the largest-ever randomized trial of an anti-cancer virus, and it gives evidence that the concept could soon be transferred into clinical studies after decades of refinement in the lab. T-VEC injections were compared with injections of GM-CSF only, which is sometimes used to treat people who have poor immunity caused by cancer treatment. About 16 percent of patients who received the T-Vec treatment exhibited lasting response for six months, while only 2 percent of the control group who got normal treatment showed lasting response. Professor Kevin Harrington, from the Institute of Cancer Research in London, led the trials which were held in the UK, US, Canada and South Africa. Very large moles that have been present since birth do have an increased risk of transforming into melanoma over time. The result is considered remarkable because all had highly advanced melanoma and a very poor prognosis.

Professor Kevin Harrington, from the Institute of Cancer Research in London, led the international Phase III trial conducted in the UK, US, Canada and South Africa. Melanoma has traditionally been treated surgically. Scabby mouth lesions are the main differential diagnosis. The CMV infection showed no statistically significant correlation with the histological type, age, site of lesion or sex. Early prevention, diagnosis and treatment of basal cell carcinoma are possible. Researchers opted for patients with advanced inoperable melanoma as the effects of the therapy were thus, more noticeable. Surgery is complete when no more cancer cells are detected.


It seems the common cold-sore isn’t so nasty after all. Peer review processing is performed by eminent researchers, scientists, scholars and editorial board members of Skin Diseases & Skin Care Journal. The majority of people with genital herpes treat their disease episodically, but episodic treatment is not effective at either reducing the frequency of painful lesion outbreaks or periods of asymptomatic shedding, when the majority of disease transmission occurs, said Nicholas Van Wagoner, M. “Patients showing responses beyond three years is something that up until now, we could only have imagined,” said Gillian Nuttall, Founder of Melanoma UK. The team found that 16.3% of patients who received the T-VEC treatment experienced a stronger response lasting more than six months, compared with only 2.1% of the patients who simply were administered the control immunotherapy. 163 patients in the clinical trial, with less advanced melanoma (stage 3 and stage 4) — treated with the T-VEC — survived on average 41 months compared to 21.5 months for 66 patients with a similar stage treated with other immunotherapy. Results were more pronounced in patients with less advanced skin cancer and in those who had no prior treatment, indicating T-VEC could be a first-line treatment.

The new treatment, known T-VEC, has already been submitted to major US and European medical agencies for approval, and could be available to the public by next year. The viral treatment works by multiplying in cancer cells and bursting them from within and directing the immune system to attack the tumour. The new treatment does not harm healthy cells or tissue and has fewer side effects. And many of the patients are now cancer-free. The trial found, overall, significantly more people responded to treatment for more than six months with T-VEC (16.3%) than with GM-CSF injections (2.1%). Imlygic is a genetically altered form of the herpes simplex virus that can cause genital and oral herpes. Patients with stage III and early stage IV melanoma treated with T-VEC (163 people in all) lived an average of 41 months.

The drug is administered once every two weeks for up to 18 months, and while participants in the trial received flu-like side effects after the first few injections, this was far preferable to the side effects that come with chemotherapy drugs. Results were more pronounced in patients with less advanced skin cancer and in those who had no prior treatment, indicating T-VEC could be a first-line treatment. In the trials held in the United Kingdom, the United States, Canada and South Africa, scientists used the same herpes virus that causes cold sores, though the agent had been modified to make it harmless to patients — but lethal to cancer, Britain’s Sky News noted. T-VEC injections were compared with injections of GM-CSF only, which is sometimes used to treat people who have poor immunity caused by cancer treatment. Professor Kevin Harrington, from the Institute of Cancer Research in London, led the international Phase III trial conducted in the UK, US, Canada and South Africa. Please enable JavaScript to view the comments powered by Disqus. T-VEC is a modified derivative of the herpes virus that causes cold sores.

A study involving 436 late-stage melanoma patients at 64 centers around the globe, published in the current issue of the Journal of Clinical Oncology, shows that those injected with a genetically-modified version of the herpes simplex virus known as T-VEC responded better than a control group.