2013; Cui et al. The first human enteroviruses (EV) discovered after poliovirus were the Coxsackie viruses. The study was approved by the hospital Ethics Committee. 2016). Today, the polymerase chain reaction (PCR) applied to cerebrospinal fluid technique allows us to obtain accurate diagnosis within a short time, on the different viral agents that cause these neuroviroses. Enterovirus RNA was detected in CSF in 47 of 96 (48.9%) children tested. Passage of some strains of virus by way of air droplets can lead to respiratory illness.

There is continuing activity of EV-71 in our neighbourhood for the last 3 decades. [Medline]. Although AM has a fairly good prognosis, children who have contracted AM are recommended to be admitted to the hospital as it is sometimes, although rarely, is accompanied by death or lethal sequelae such as encephalitis or status epilepticus (1). J infect Dis 1994;169:905-8. Copyright: © 2014 Tao et al. 2016 Jun 3. Passage of some strains of virus by way of air droplets can lead to respiratory illness.

Aseptic meningitis caused by EV71 and coxsackie A viruses–the predominant pathogens for the hand, foot, and mouth disease–is currently an important concern in mainland China. Enteroviruses are responsible for a wide variety of diseases in children and adults, including nonspecific febrile illnesses, neonatal sepsis, meningitis, and encephalitis (16). The virus-encoded RNA-dependent RNA polymerase does not possess proofreading property thereby endowing high mutation rate during replication [1]. Enterovirus detections by serotype with specimen type, collection date, and demographic information are reported monthly by participating laboratories to CDC, which summarizes the data and disseminates the results. EV71 usually causes relatively benign hand, foot and mouth disease and herpangina in children [1]. Results: Enterovirus detection rate in all 118 Cerebrospinal fluid specimens was 10.16%. Some enteroviruses have been shown to have the ability to infect the central nervous system and cause various neurological symptoms, such as encephalitis, meningitis, paralysis and ataxia.

Additionally, some reports have suggested that enteroviral diseases may be expanded to other serious human ailments such as autoimmunity, type 1 diabetes9), Sjögren’s syndrome10), various neurological disorders11), and some tumors12). EV71 C4a remained the predominant subgenotype circulating in Shanghai. EV isolates were typed by the standard method of virus neutralization (Lim-Banyesch-Melnick immune serum pools) (4). It was noted that if serotype assignment is made based on Blast comparisons with the GenBank database sequences, there is a potential for inaccurate serotype assignment since contemporary isolates submitted into GenBank may have been serotyped based on the VP4 sequence, which can reassort independently of the VP2-VP3-VP1 segment. The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis. Conèixer el perfil del serotipus infecciós, no obstant, no modificarà la situació, ja que no existeix tractament contra els enterovirus. Most patients with HFMD experience a mild disease course, but recent reports on the outbreak of EV71 infection in various countries, including Taiwan, People’s Republic of China, and Malaysia, indicate that some EV71-infected persons have severe neurologic complications or systemic disease (3,4).

No enterovirus was isolated from any site for the 67 patients with febrile seizures. The aims of this surveillance were to describe the extent of the outbreak and the clinical features of cases to aid in their identification and management. If you continue browsing the site, you agree to the use of cookies on this website. Specific EV71 PCR was conducted to identify the genotype of the detected EV71 viruses. Our assays are validated for multiple specimen sources, including CSF, plasma, respiratory specimens, body fluids, ocular swabs, dermal swabs and others. Said to be the most common type of meningitis, viral meningitis occurs because certain viruses have made their way into your body. This new reliable EV RNA detection test is suitable for clinical diagnosis of EV-related meningitis and may improve the management of EV-related neurological syndromes.

CSF-IFN-γ did not distinguish between viral and bacterial meningitis. This report aimed to study some epidemiological characters of this outbreak and to find differentiating criteria between viral and bacterial meningitis. It has been shown that serum procalcitonin (PCT) can be used to differentiate bacterial from viral meningitis in children in all cases. The Enterovirus (EV) genus of the Picornaviridae family is divided into twelve species. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Human enterovirus 71 (EV71) epidemics have affected various countries in the past 40 years. Enteroviruses are the main pathogens involved in viral meningitis (85–90%).2 Risk factors for meningitis caused by these virus are young age, poor hygiene practices (such as lack of hand-washing) and contact (such as that from staff in schools and nurseries).3,4 Other viruses that are frequently involved are herpes simplex type 2 and the varicella-zoster virus.5 Viral meningitis epidemics caused by enteroviruses have been reported in the summer.6 Therefore, enteroviruses are the main cause of viral meningitis with epidemic and endemic patterns.