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496–502. T. Although the probosciviruses have evidently coevolved with their hosts throughout elephantid evolution and would also be expected to persist in a long-term latent state in animals that survive infection, it appears that unknown factors may predispose infected elephants to develop fatal manifestations of infection. Matching data for the prototype EEHV1A(Raman, EP22) strain from that study is also included in Fig. Make sure there is a sufficient supply of clean drinking water at all times. Evaluation of EEHV1A-1B chimeric domain CD-I patterns and boundaries relative to EEHV6. 2006;87:2781–2789.

The entire combined inverted and direct repeat arrangement encompassing the predicted EEHV4A(Baylor) 1,180-kb Ori-Lyt domain from map coordinates 92120 to 93324 is illustrated in the dot matrix self-comparison plot presented in . D. 133-136. However, accurate and timely detection of LH2 is needed at least daily and at times twice daily during estrus. Asian elephants are also the victims of poaching for ivory, meat and leather. Three European zoos (Zoo 1, 2 and 3) provided Asian elephant serum or plasma samples for a longitudinal seroprevalence study ranging from 250 up to 600 days for multiple animals in their herds. Support for this study was provided by the Houston Zoo and a grant from the Dan L.

Determining Pharmacokinetic Characteristics of the Antiviral Drug Ganciclovir in Asian Elephants Elephant endotheliotropic herpesvirus (EEHV) is a significant cause of mortality in young Asian elephants, contributing to at least 65% of juvenile deaths in the captive population. That February, they got an unpleasant surprise. 2000. Predicted outer surface glycoprotein (gL) was cloned utilizing information from the complete genome sequence of EEHV1A [17]. Dr. She paced even more after Chai’s daughter Hansa was born, thanks in part to a basic flaw in those quarters: They’re arranged like a tunnel, with just one entry through the main chamber. Generalized reddening and mild enlargement of all examined visceral and subcutaneous lymph nodes was also noted.

Journal of General Virology 87 (Pt 10): 2781-2789. Pilocarpine should not be used in secondary glaucoma cases. But Maggie is, in fact, thriving – doubtless to the extreme annoyance of the AZA. At SVMS, we are interested in the evolutionary biology, vector biology and diagnosis of emerging viruses. Injuries were observed in the right hind leg and above the tail. Curt Griffin, looking at African elephant endocrinology and investigating long-term stress response comparison of semi-captive, released and free-ranging savannah elephants in the Okavango Delta. Thought to have originated from the release of infected African clawed frogs (who are themselves resistant) into non-native habitats, chytrid is solely responsible for the almost 90% decline in global amphibian numbers.

Asian elephants are endangered and it’s hoped that the work being done in captivity will hold the key to unlocking the information researchers need to make a positive breakthrough. Possible implications of this case especially on breeding and keeping elephants are discussed briefly. Since the collaboration began, researchers say they have gained a whole new understanding of the virus, learning it’s not as rare as once thought. By means of PCR and subsequent sequence analysis a DNA-sequence typical for the elephants herpesvirus could be obtained which showed an identity of 97% with the terminase sequence of the elephant herpesvirus described by American authors. maximus from Sri Lanka, the E. Here, we have determined the complete genomic DNA sequence of a strain of EEHV4 obtained from a trunk wash sample collected from a surviving Asian elephant calf undergoing asymptomatic shedding during convalescence after an acute hemorrhagic disease episode. There is currently no knowledge of the prevalence of EEHV in Nepal, a country within the natural range of wild Asian elephants.

The complete 177,136-bp EEHV1A (Kimba) genome consists of 115 identified likely open reading frames (ORFs), including 14 for which we were able to assign likely splicing patterns. Given the virus’ severity, Samson’s caretakers consider their 3,500-pound patient fortunate so far. Furthermore, to further amplify Jim Wellehan’s comments, we now know of 11 different species or sub-species of elephant herpesviruses, which fall into 2 very different groups, the probosciviruses or EEHVs, and the elephant gammaherpesviruses discovered by Jim Wellehan. Stanton, Joseph P. Y. Tell a friend about us, add a link to this page, or visit the webmaster’s page for free fun content. Antiviral drugs used for human herpes virus strains are somewhat effective but require quick detection and aggressive administration (Hayward, 2012).

— Dickerson Park Zoo’s nationally recognized breeding program was dealt a blow Wednesday when the first Asian elephant calf born by artificial insemination died of a mysterious herpesvirus. Objective: To investigate the pathogenesis and transmission of elephant endotheliotropic herpesvirus (EEHV1) by analyzing various elephant fluid samples with a novel EEHV1-specific real-time PCR assay. In keeping with the best practices for elephant management, the Zoo has invested in a state-of-the-art exhibit: Elephant Trails. The elephant endotheliotropic herpesvirus (EEHV) is now recognized as one of the main causes of death of young Asian elephants (Elephas maximus) in North American zoos.