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Pantry, S, Medveczky, M, Arbuckle, J, Luka, J, Montoya, J., Hu, R. Michael Kranish wrote that “Doctors, nurses, and others who receive the smallpox vaccine might need a three week furlough because, in rare cases, the vaccination could spread sickness, the plan says. In the study, thirty CFS patients with elevated IgG antibody titers against HHV-6 and EBV were randomized 2:1 to receive valganciclovir (VGCV) or placebo for 6 months in a double-blind, placebo-controlled trial. Montoya showcased some of the findings coming out of his large immune studies at Stanford. Both HHV-6A and B have been found integrated into the chromosomes of immunocompetent patients at persistently high levels of viral DNA in blood, sera, and hair follicles (Ward 2006). This may sound absurd but I dated a girl several years ago who had polio as a child. Some viruses have been associated with CFS etiology, specially herpesviruses, enteroviruses and retroviruses.

Author manuscript; available in PMC 2016 February 18. Dr. HHV-6 reactivation has been shown to play a role in the pathogenesis of AIDS and several other diseases. Pantry, S, Medveczky, M, Arbuckle, J, Luka, J, Montoya, J., Hu, R. Human herpesvirus-6 (HHV-6) has been implicated in the development of a diverse array of neurologic conditions, including seizures, encephalitis, mesial temporal lobe epilepsy (MTLE), and multiple sclerosis (MS) [Dewhurst et al., 1997; Dewhurst, 2004; Birnbaum et al., 2005; Fotheringham and Jacobson, 2005; Isaacson et al., 2005; Fotheringham et al., 2007a,b]. At least six methods are used by to detect HHV-6. The diagnosis of human herpesvirus 6 (HHV-6) infection represents a complex issue because the most widely used diagnostic tools, such as immunoglobulin G antibody titer determination and qualitative DNA PCR with blood cells, are unable to distinguish between latent (clinically silent) and active (often clinically relevant) infection.


Many theories have been postulated, but no single theory has been pointed out in the etiopathogenesis. These include fibromyalgia syndrome, myalgic encephalomyelitis, neurasthenia, multiple chemical sensitivities, and chronic mononucleosis. Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. New research suggests that HHV-6 may play a role in several chronic neurological conditions including mesial temporal lobe epilepsy, status epilepticus and chronic fatigue syndrome. This page provides overview information on the known and suspected causes of chronic fatigue syndrome, as well basic details about treatments. In a double-blind study, 234 subjects with severe CFS were treated with either 400 mg rintatolimod or placebo twice weekly. Montoya showcased some of the findings coming out of his large immune studies at Stanford.

CFS patients had a high prevalence (51%) of one of four Mycoplasma species (OR = 13.8, 95%CL 5.8–32.9, P >0.001) and often showed evidence of co-infections with different Mycoplasma species, Chlamydia pneumoniae (OR = 8.6,95%CL 1.0–71.1, P >0.01) and/or active Human Herpes Virus-6 (HHV-6) (OR = 4.5,95%CL 2.0–10.2, P >0.001). In a variable percentage primary infections are followed by a short acute disease, exanthema subitum. Biofilms. Patients report various nonspecific symptoms, including weakness, chemical sensitivities, allergies, poor immune function, muscle pain, impaired memory and/or mental concentration, insomnia, and post-exertional fatigue lasting more than 24 hours. Here luciferase immunoprecipitation systems (LIPS) was used to develop HHV-6 serologic diagnostic tests using antigens encoded by the U11 gene from HHV-6A (p100) and HHV-6B (p101). This suggestion is based on (1) epidemiological evidence of childhood exposure to infectious agents and increase in disease exacerbations with viral infection1,2; (2) geographic association of disease susceptibility with evidence of MS clustering3−4; (3) evidence that migration to and from high-risk areas influences the likelihood of developing MS (refs. If we are to believe a recent federal review, my friend’s condition is all in her mind.

Source University of Alabama at Birmingham, Birmingham Alabama. According to a group of dermatologists in Italy, a suprising 62% of women who developed PR early in their pregnancies miscarried, and HHV-6 DNA was found in fetal tissue of 3 out of 4 stillborns tested. We studied 52 patients fulfilling the criteria of Centers for Disease Control (CDC) for CFS and a control group of 51 matched healthy blood donors. Of particular interest are the viral components of the microbiota. CFS was initially termed encephalomyalgia (or myalgic encephalomyelitis) because British clinicians noted that the essential clinical features of CFS included both an encephalitic component (manifesting as cognitive difficulties) and a skeletal muscle component (manifesting as chronic fatigue). The name CFS itself is controversial as many patients and advocacy groups, as well as some experts, want the name changed as they believe that it stigmatizes by not conveying the seriousness of the illness. (1998).

· Design: Cohort study with comparison to matched, healthy control subjects. Chronic fatigue syndrome (CFS) is a complex, heterogeneous disease characterized by debilitating fatigue that is not improved with bed rest and worsens after physical activity or mental exertion.