The association between initiation of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection and possible herpes simplex virus type 2 (HSV-2) shedding and genital ulcer disease (GUD) has not been evaluated. Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are important causes of acute neurologic illness. Herpes viruses are large, enveloped DNA viruses. HSV is most commonly treated with antiviral therapies because studies have shown the efficacy of them in reducing the duration and severity of genital and oral herpes.. Antiviral treatment of herpesvirus infections is rapidly changing since the advent of new drugs with improved oral availability. Twenty-five percent of American women and 20% of American men have genital herpes. We aim to assess the relative effectiveness and safety of competing oral antiviral drugs (ACV, FCV and VCV) prescribed to suppress recurrent genital herpes.
For the primary infection of genital herpes, antiviral therapy with acyclovir is the gold standard. Editor’s Note: Experts have reported that the annual incidence of new genital herpes infections in the United States is greater than that of all other sexually transmitted infections combined. Herpesvirus infections of the central nervous system (CNS) are a significant cause of morbidity and mortality, including long-term neurologic sequelae. One of the most deleterious consequences of maternal infection with herpes simplex virus is neonatal herpes, which results in death or significant neurodevelopmental impairment in the majority of infected babies. The mainstay of antiviral therapy for the alpha-herpesviruses [herpes simplex virus (HSV)-1, HSV-2, and varicella zoster virus (VZV)] over the past 40 years has been the nucleoside analogues such as aciclovir. One of the most deleterious consequences of maternal infection with herpes simplex virus is neonatal herpes, which results in death or significant neurodevelopmental impairment in the majority of infected babies. Herpes simplex virus (HSV) infections in immunocompromised patients are more severe and invasive than in non-immunocompromised patients.
Corey, L, Ashley, R, McCloskey, J, Denham, I, Patten, J, Pell, C, Waddell, R, Sodre, CT, Bouchard, C, Diaz-Mitoma, FJ, Lassonde, MG, Romanowski, B, Sacks, SL, Trottler, S, Gubelin, W, Guglielmetti, A, Diaz, J, Rubiano, N, Roed-Petersen, J, Thestrup-Pedersen, K, Wulff, HC, Kivimagi, K, Poder, A, Paavonen, J, Saari, S, Simpanen, AL, Morel, P, Ortonne, JP, Cardamakis, E, Mourelou, O, Bornstein, J, Dolitzky, M, Dainys, B, Laiskonis, A, Soto, RG, Pulido Olivares, VH, Cairo, I, Arama, V, Balasoiu, V, Capalna, M, Giurcaneanu, C, Popescu, S, Tarlea, V, Koubanova, A, Martchenko, L, Semenova, T, Stratchounsky, L, Ballesteros, J, Varela, JA, Strand, A, Atakan, N, Ozarmagan, G, Adkins, GM, Baker, DA, Beutner, KR, Beyerlein, RA, Brady, R, Cabezas-Mijuste, M, Clark, S, Conant, M, Corey, L, Drehobl, MA, Douglas, J, Faro, S, Fife, KH, Funk, S, Gartman, D, Garza, G, Hart, DC, Holmes, JA, Koltun, WD, Kraus, SJ, Kurtz, T, Landwermeyer, MA, Leone, PA, Levin, MJ, Marbury, TC, Marlowe, SI, Marques, A, Mertz, G, Nett, R, Pogue, B, Poretz, DM, Rosen, J, Rowe, DH, Salazar, G, Schacker, TW, Seraly, M, Spencer, RP, Stern, J, Stone, S, Thomas, E, Tyring, SK, Wald, A, Warren, T, Whiting, DA, Wiener, ML, Wiesenfeld, H & Bowman, C 2004, ‘Prevention of herpes simplex virus type 2 transmission with antiviral therapy’ Herpes, vol 11, no. This article has been cited by other articles in PMC. Worldwide, herpes simplex virus type 2 (HSV-2) infection is the biggest cause of genital ulcer disease, and is responsible for the majority of cases of genital herpes. For persons (heterosexual or homosexual) with HIV and HSV infection, the effects of episodic treatment of genital ulcers on HIV shedding and the risk of transmission of HIV to HIV-uninfected partners. Hep C – We have studied Hep C and other forms of hepatitis for more than 15 years. Herpesvirus infections of the central nervous system (CNS) are a significant cause of morbidity and mortality, including long-term neurologic sequelae. Corey L, Wald A, Celum CL, Quinn TC.